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NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of your body

While the exact mechanisms remain to be agreed upon, both in vitro and in vivo experiments suggested several potential pathways for APOE4, including enhancing A production (promoting APP transcription and processing), facilitating A aggregation (interaction with soluble and fibrillary A aids in seeding/oligomerization/protofibril formation), and impairing A clearance (disrupted glial and enzymatic A degradation functions, and A removal rate from the brain)

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doi: 10.1093/humupd/dmaa045 72